San Francisco 49ers wide receiver Brandon Aiyuk will be the first guest to appear on his teammates' show Cleats and Convos with Deebo Samuel.

Already without running back Christian McCaffrey, the 49ers are poised to be without receiver Deebo Samuel for a couple of weeks after he strained his calf late in Sunday's game at Minnesota.

Sunday was another relatively light outing for the San Francisco 49ers defense, which logged 54 snaps after getting just 51 six days earlier against the New York Jets.

The San Francisco 49ers offense got a bit thinner when one of their top wideouts suffered a calf strain in their Week 2 loss to the Minnesota Vikings.

The San Francisco 49ers loss to the Minnesota Vikings will likely be headlined by a historic connection between former Niner Sam Darnold and his new star pass catcher Justin Jefferson. After stopping the 49ers on fourth and goal at the goal line,

Fred Warner and the San Francisco 49ers couldn't get the defense stops they needed during their rough 23-17 loss to the Minnesota Vikings on Sunday.