We were the first in Europe to develop chemotherapeutic agents. We discovered, and with The Royal Marsden developed, the chemotherapy drugs busulfan, chlorambucil, melphalan and carboplatin, which are ...

Large Cleaved and Immunoblastic Lymphoma May Represent Two Distinct Clinicopathologic Entities Within the Group of Diffuse Large B-Cell Lymphomas t(4;14)-positive patients had a predominance of the ...

Chemotherapy exposure created a pattern of mutations that was similar to normal aging, but the changes were premature and involved different genes. Chemotherapy can increase mutation burden and change ...

Chemotherapy drugs can kill cancerous cells through several mechanisms. There are many types of chemotherapy drugs, including alkylating agents and antimetabolites. Chemotherapy drugs are unable to ...

A recent study sought to identify an mRNA biomarker that predicts chemosensitivity across multiple solid tumor subtypes, given the significant heterogeneity in response among patients to ...

The efficacy of many alkylating chemotherapeutic agents is significantly undermined by the cellular repair protein O6-alkylguanine-DNA alkyltransferase (AGT), which removes cytotoxic alkyl groups from ...

When the sole manufacturer withdrew a critical cancer drug from Medicare and Medicaid, patients were left without options.

This is a preview. Log in through your library . Abstract This Ontario province-wide cohort study was conducted to compare the risk of adverse pregnancy outcomes in female childhood cancer survivors ...