Nature

Differential signaling networks of Bcr–Abl p210 and p190 kinases in leukemia cells defined by functional proteomics

The two major isoforms of the oncogenic Bcr–Abl tyrosine kinase, p210 and p190, are expressed upon the Philadelphia chromosome translocation. p210 is the hallmark of chronic myelogenous leukemia, ...
Medscape

Signaling Pathways Activated by the B-Cell Receptor in Chronic Lymphocytic Leukemia

This article was supported by Regione Veneto, Ricerca Sanitaria Finalizzata; Fondazione G Berlucchi per la Ricerca sul Cancro; Fondazione Cassa di Risparmio di Verona, Vicenza, Belluno e Ancona and ...
ascopubs.org

Gene expression analysis of B-cell receptors (BCR) pathway for identification of PDE4B gene as potential therapeutic target to overcome glucocorticoid resistance in primary CNS ...

Association of increased progression-free survival in primary glioblastomas with lymphopenia at baseline and activation of NK and NKT cells after dendritic cell immunotherapy. Comparison of ...
ascopubs.org

Association of activated BCR and PI3K pathways with responses and longer PFS to single-agent copanlisib in heavily pretreated patients with indolent and aggressive NHL.

Clinical significance of gastrointestinal involvement in human immunodeficiency virus (HIV) patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). Phase I study of recombinant human ...
Miami University

C45 - B Cell methods of FCRL1 localization to BCR complex

B Cells are a type of lymphocyte whose primary purpose is to generate highly specific antibodies in response to a foreign antigen. B Cells are a type of lymphocyte whose primary purpose is to generate ...
The American Journal of Managed Care

BTK Inhibition in CLL: Successes and Challenges

A review of current data identified areas of progress in Bruton tyrosine kinase (BTK) inhibition for patients with chronic lymphocytic leukemia (CLL). Virtually every medication carries pros and cons, ...