Beta-lactamase enzymes are a principal mechanism by which bacteria deactivate beta-lactam antibiotics, undermining treatments for a range of infections. Molecular dynamics approaches have become ...

Resistance to carbapenems among Enterobacterales is primarily achieved by production of carbapenemases, which are enzymes capable of hydrolyzing carbapenem antibiotics and most other beta-lactams and ...

In a recent study published in the Microbiology Spectrum Journal, researchers suggest that Escherichia coli ST2797 could potentially be a new type of extended-spectrum beta-lactamase (ESBL) ...

Intravenous cefepime-zidebactam was significantly superior to meropenem in phase III trial ...

Enzyme-catalysed antibiotic degradation, or modification or degradation of antibiotics or their targets, is one of the major mechanisms of antibiotic resistance. Plasmid borne genes encoding modifying ...

Lately I have become intrigued by the word, innovation. Innovation is used as a criterion for funding grants, for status in reviews of our antibiotic pipeline, for intelligence, imagination and many ...