Dupilumab, a fully human monoclonal antibody, blocks interleukin-4 and interleukin-13 signaling, which have key roles in eosinophilic esophagitis. We conducted a three-part, phase 3 trial in which ...

The appraisal committee considered evidence submitted by Dr Falk Pharma UK, a review of this submission by the evidence review group (ERG), NICE's technical report, and responses from stakeholders.

Patients with eosinophilic oesophagitis (EoE) unresponsive to off-label swallowed topical corticosteroids (STCs) demonstrated a positive response to an oesophageal-targeted budesonide formulation.

Sanofi and Regeneron’s Dupixent (dupilumab) has been approved by the European Commission as the first and only targeted medicine for eosinophilic oesophagitis (EoE), the companies announced.

Please note that following on from information provided to NICE by the company in November 2022, the appraisal of "Oesophagitis (eosinophilic, aged 12-65) - benralizumab ID5093" was suspended from ...

Sanofi and Regeneron’s Dupixent (dupilumab) has demonstrated significant improvements in paediatric patients with eosinophilic oesophagitis (EoE), according to phase 3 results published in the New ...

Esophageal eosinophilia was initially considered solely a manifestation of gastroesophageal reflux disease (GERD). However, in the mid-1990s, experienced clinicians identified esophageal eosinophilia ...

—Incidence of eosinophilic esophagitis has increased, and it is now a highly prevalent disorder. A review of published literature shows a delay in diagnosis, a lack of standard treatments achieving ...

Refractory eosinophilic oesophagitis (EoE) can be defined as persistent eosinophilia with incomplete symptom resolution, and persistent endoscopic findings after a PPI trial and after topical steroid ...

Eosinophilic oesophagitis (EoE) was first described in the early 1990s. Although initially reported to be a rare entity, EoE has rapidly become a regularly diagnosed disease with a prevalence of ...

Eosinophilic esophagitis (EoE) is an allergic condition that causes inflammation in a person’s esophagus, which is the food pipe. People with EoE may need to avoid certain foods that trigger symptoms.