Drugs that mimic GLP-1 are widely used to treat diabetes and obesity, but it is not fully understood exactly how they produce many of their beneficial effects. Investigators from The Salk Institute ...

Diabetes and obesity drugs also lead to large reductions in adverse cardiovascular events, and the benefits aren’t just down ...

A peer-reviewed study of more than 46,000 older adults with type 2 diabetes found that patients who started GLP-1 receptor agonist drugs faced an 11 percent higher risk of fragility fractures compared ...

GLP-1 drugs may help boost heart attack recovery by lowering the risk of major complications, an animal study suggests.

GLP-1 receptor agonists may confer neuroprotection via reduced neuroinflammation, inhibited apoptosis, and vasodilatory effects that enhance cerebral perfusion through cAMP and VEGF-related pathways.

Can the neurovascular effects of GLP-1s play a role in treating migraine?

A biased GLP-1 receptor agonist maintained glycemic control while reducing side effects in preclinical models. By selectively activating cAMP, this biased agonist approach may support safer diabetes ...

Dedifferentiated liposarcoma lacks effective IGF-1→PPAR-γ adipogenic signaling due to epigenetic silencing of PPAR-γ2, with ...

For the more than 48 million Americans with substance use disorders, including a disproportionate share of veterans, GLP-1 drugs are not yet an approved addiction treatment. But the evidence base is ...