A manometric technic is described for the diagnosis of Hirschsprung's disease without the necessity of deep-muscle rectal biopsy. Separate pressure recordings were obtained from the internal and ...

Assembled Multipurpose Instrument for Rectal Biopsies (A) and Actual Size of the Biopsy Capsule (B), Which Has Been Removed to Show the Knife Attached to the Pull Wire. Three to 5 biopsies are ...

Dr. Marc Levitt is Surgical Director for the Center for Colorectal and Pelvic Reconstruction at Nationwide Children's Hospital. He contributed this article to Live Science's Expert Voices: Op-Ed & ...

When a newborn is unable to pass stool, the cause could be Hirschsprung’s Disease, a rare congenital disorder that can lead to serious complications. Dr. Michael Rollins explains the disease and how ...

A new surgical procedure successfully addresses a common lingering challenge—incontinence—faced by some families with young children who have undergone surgery for Hirschsprung disease. This ...

FIGHTING TO GET BETTER TREATMENT OPTIONS FOR A RARE CHILDHOOD CONDITION. IT’S CALLED HIRSCHSPRUNG DISEASE. THE EARLIEST SIGN IN A NEWBORN IS OFTEN CONSTIPATION. THERE ARE TREATMENTS AVAILABLE. HERE’S ...

Scientists at the University of Michigan Medical School have identified defective stem cells as the key to a serious, sometimes life-threatening, intestinal disorder called Hirschsprung's disease, ...

Hirschsprung disease is a congenital disorder clinically characterized by the absence of colonic ganglia and genetically by extensive heterogeneity. Genes involved include RET, GDNF, EDNRB and EDN3.

Perhaps the most important gene in Hirschsprung disease is Ret, a receptor tyrosine kinase that is mutated in the majority of patients with the disease. Ret is expressed by the neural crest cells in ...

The institutional review board of The University of Hong Kong together with the Hospital Authority granted ethical approval for this project (IRB: UW 03-227 T/227). Blood samples were drawn from ...

Ankush Gosain, MD, PhD, of Le Bonheur Children's Hospital and the University of Tennessee Health Science Center has focused his research on determining the mechanisms underlying abnormal development ...

Last week news broke of a 22-year-old man in China who had a large section of his colon removed. The man, Zhou Hai, had been constipated for a number of months. After seeking medical help for ...