The insulin receptor (IR) is a prototypical receptor tyrosine kinase that orchestrates critical cellular processes, including metabolism, cell growth and differentiation. Activation of the IR involves ...

During the American Diabetes Association national conference this year in Philadelphia, scientists gathered to discuss recent advances in this field at a session on positive and negative elements in ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to ...

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...

In 2021, a research team discovered the insulin-inhibitory receptor 'Inceptor' and its role as a suppressor of the insulin signaling pathway. Now, the researchers have unlocked another, even more ...

Developing resistance to insulin is a key step on the road to diabetes, making insulin resistance a target for treating metabolic dysfunction. Insulin orchestrates blood glucose levels by signaling ...

A new study uncovers how endothelial cells contribute to insulin resistance in obesity-associated diabetes, highlighting adrenomedullin as a potential therapeutic target. Study: Endothelial insulin ...

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