Researchers create a network of interacting proteins -- or interactome -- to aid drug discovery. Scientists at Open Targets, EMBL's European Bioinformatics Institute (EMBL-EBI), and GSK are revealing ...

As our bodies run multiple parallel processes, they shuttle a flurry of messages around inside—often as protein-metabolite interactions (PMIs), where small molecules bind to a protein and initiate or ...

It has been said that the journey of a thousand miles begins with a single step. Functional genomicists took that proverbial step earlier this month when a group led by Erich Wanker, of Berlin?s Max ...

G protein-coupled receptors (GPCRs) are vital membrane proteins involved in cellular and physiological processes, including sensory perception, signaling, neurotransmission, and immune response.

Researchers at the Josep Carreras Leukaemia Research Institute have developed a method to analyze long-range interactions in the DNA -the interactome- from a very low amount of starting material. The ...

Four weeks after Erich Wanker?s team published its human interactome paper, Marc Vidal?s group at the Dana-Farber Cancer Institute in Boston has followed suit. In today?s (Sept. 28) online edition of ...

Proteins that physically bind each other are generally involved in the execution of similar biological functions and shape similar phenotypes at the organismal level in health and disease. A protein ...

Universitat Autonoma de Barcelona (UAB) researchers have produced the most complete map of the bacterial essential interactome, i.e. how proteins combine and interact to perform functions essential ...

Most protein-targeting drugs are prizes that drug developers have unearthed from G protein–coupled receptor (GPCR) interactomes. So, when GPCR-targeting drugs become harder to find, one might liken ...

Scientists at Open Targets, EMBL’s European Bioinformatics Institute (EMBL-EBI), and GSK are revealing the shared basis of diseases using a map of interacting human proteins. By helping to understand ...