MeCP2 is a methyl DNA–binding transcriptional regulator that contributes to the development and function of CNS synapses; however, the requirement for MeCP2 in stimulus-regulated behavioral plasticity ...

This release is available in Spanish. A paper published online today in Molecular Cell proposes that Methyl CpG binding protein 2 (MeCP2) impacts the entire genome in neurons, rather than acting as a ...

Rett syndrome (RTT) is unique among genetic, chromosomal and other developmental disorders because of its extreme female gender bias, early normal development, and subsequent developmental regression ...

A new article proposes that Methyl CpG binding protein 2 (MeCP2) impacts the entire genome in neurons, rather than acting as a regulator of specific genes. Mutations in MeCP2 cause the autism spectrum ...

Findings bolster the idea that the functions of this protein -- MeCP2 -- are more centered on nucleosomes, rather than other forms of DNA. One particular protein lies at the heart of brain development ...

Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital and collaborating institutions have gained new insights into the ...

Researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital (NRI) have identified and characterized two regions of DNA required ...

Rett syndrome is a rare devastating neurological disorder that primarily affects young girls and manifests as an impaired ability to walk and talk, along with characteristic 'hand-wringing' movements, ...

In the February 9 Science, Adrian Bird and colleagues at Edinburgh University, Scotland, report striking results of a “cure” for Rett syndrome mice. Rett’s (RTT) is an X-linked autism spectrum ...

Rett syndrome is a rare disorder linked to autism that affects brain development. Microglia, the resident immune cells of the central nervous system, have been implicated in the development of Rett ...

Gene duplications are a common cause of intellectual disabilities and autism as well as various other neurological disorders. In a new study that appears online in the journal Nature, Dr. Huda Zoghbi, ...

Parents are usually the first to notice that something is wrong. A previously healthy toddler suddenly seems to have lost interest in their fellow human beings and the environment. First learned words ...