The mevalonate pathway is central to the biosynthesis of isoprenoids and sterols, underpinning a range of essential cellular processes. Farnesyl diphosphate synthase (FPPS) is a pivotal enzyme in this ...

The team demonstrated for the first time that atorvastatin can directly attack liver cancer cells by blocking the " mevalonate pathway," a metabolic route crucial for cancer cell survival. This ...

Acute myeloid leukemia (AML) is a rare and aggressive hematologic malignancy. AML progresses rapidly and is indicated by an excess of immature white blood cells. It is caused by high mutational burden ...