This is a preview. Log in through your library . Abstract It is widely appreciated that neurotransmission systems interact in their effects on human cognition, but those interactions have been little ...

Little is known about acetylcholine (ACh) modulation of central visual processing in humans. Receptor densities in visual brain regions are differentially distributed suggesting that receptor subtypes ...

The production of toxic Aβ peptides from amyloid precursor protein (APP) proceeds via the sequential cleavage of the extracellular domain by β-secretase, followed by an intramembrane cut by ...

Vanderbilt University has divulged muscarinic M1 receptor positive allosteric modulators (PAMs) reported to be useful for the treatment of pain, Alzheimer’s disease, schizophrenia, attention deficit ...

It has been amply proven that smoking can cause serious diseases such as emphysema and cancer. A new study, however, shows that pharmacological stimulation of a specific type of nicotinic receptor in ...

The muscarinic receptor agonist xanomeline has antipsychotic properties and is devoid of dopamine receptor–blocking activity but causes cholinergic adverse events. Trospium is a peripherally ...

Cisbio Bioassays, has announced that it has expanded its catalogue of Tag-lite® fluorescent ligands, used for the investigation and screening of G-protein coupled receptor (GPCR) activity, to 43 ...

BOSTON--(BUSINESS WIRE)--Karuna Pharmaceuticals, focused on targeting muscarinic receptors for the treatment of disorders marked by psychosis and cognitive impairment, today announced the completion ...

What would you say if we told you that an addictive, cancer-causing substance could help you safely stop using another addictive, cancer-causing substance? Sure, it sounds far-fetched. But it may be ...

Neurocrine Biosciences (NBIX) may be undervalued, with strong Ingrezza growth, Crenessity's billion-dollar potential, and a ...