The immune system responds to an infection by producing antibodies that recognize and bind to the cell surface of the pathogen, thus marking it as an intruder and triggering an immune response. For ...

Trypanosome parasites transmitted by tsetse flies cause devastating diseases in humans and livestock. Different subspecies infect different hosts: Trypanosoma brucei brucei infects cattle but is ...

Using cryo-electron microscopy, researchers have analyzed the structure of trypanosomes parasites in details and revealed one of their potential weak points, which has remained undetected until now.

Researchers from Sebastian Zoll’s group at IOCB Prague determined the first cryo-EM structures of a surface receptor of the human-infective parasite Trypanosoma brucei gambiense in complex with human ...

A parasite which has devastating impacts on agriculture and human health is the first pathogen to have its proteins located and mapped within its cells—providing clues to their function and helping to ...

African trypanosomes establish deadly, chronic infections of trypanosomiasis in the bloodstream by using repetitive 70-bp regions in the genome to regularly change out the active coat protein gene.

Australian trypanosomes are protozoan parasites that infect a diverse range of native wildlife, from marsupials to monotremes, with significant implications for conservation and biosecurity. Recent ...

The capacity to synthesize vitamin C (ascorbate) is widespread in eukaryotes but is absent from humans. The last step in the biosynthetic pathway involves the conversion of an aldonolactone substrate ...

Parasites that cause the deadly illness known as sleeping sickness can spread beyond their native Africa as a result of mutations to key genes, a study shows. A parasite which has devastating impacts ...