The ATM sequence, termed intron-splicing processing element (ISPE), is complementary to U1 snRNA. Experiments with a hybrid minigene confirmed the importance of the ISPE sequence; interaction with U1 ...

"Our work provides exciting new insights into the mechanism of minor intron recognition and sheds light on the evolution of the splicing machinery.

Pre-tRNA is converted into mature tRNA, which has a complex 3D structure, through a series of steps, including the excision of an intron by specific endonucleases. In humans, this is catalyzed by the ...

They also observed that intron retention decreased gene expression. The researchers investigated the effect of a splicing mutant on intron retention and gene expression. They observed that while ...

But in this case, the presence of the repeat sequences somehow misdirects the splicing machinery, causing a portion of the intron, including the repeats, to be retained in the mature RNA.

Preliminary studies have shown that SARS-CoV-2 infection suppresses global mRNA splicing, hence infection with betacoronaviruses could induce a greater degree of intron retention.

Role of alternative splicing in cancer Splicing has a key role in oncogenesis, tumor suppression, and metastasis in cancer-related genes.