The membrane protein Nogo-A is a major player in the neurite growth-inhibitory and regeneration-inhibitory effects exerted by myelin in the mammalian brain and spinal cord. In the injured CNS, ...

Research headed by teams at the University of Rochester Center for Translational Medicine and the University of Copenhagen describes for the first time how a spreading wave of disruption and the flow ...

Proteinase-activated receptors (PARs) are a class of G-protein-coupled receptors, the main peculiarity of which is that they are activated by proteolytic cleavage. Four PARs have been cloned so far, ...

Fenoldopam mesylate, a benzazepine derivative, is the first selective dopamine-1–receptor agonist that has been approved for clinical use. Administered parenterally, it acts predominantly as a ...

Blocking a receptor involved in prostaglandins reduces pain while allowing inflammation to proceed normally, according to findings from animal and cell studies. Researchers at the NYU Pain Research ...

An international team of researchers has discovered a new component of the peripheral nervous system that acts by increasing energy metabolism in the body. The finding paves the way for the ...

Chemotherapy-induced nausea and vomiting (CINV) represents one of the most distressing and debilitating side effects ...

Injured axons instruct Schwann cells to build specialized actin spheres to break down and remove axon fragments, thereby starting the regeneration process. Damaged peripheral nerves can regenerate ...

Sometimes pain is a necessary warning signal; for example, if we touch something very hot and it burns, we know to move our hand away. But chronic pain can destroy a person's quality of life, and it ...

Researchers at Rice University have revealed a previously unknown function of opioid receptors in the development of the enteric nervous system (ENS), often referred to as the "brain in the gut." This ...

Nerve cell bodies clustered outside the central nervous system (CNS) are called ganglia. These structures are fundamental to the peripheral nervous system (PNS), serving as relay stations and ...