Gut

Luminal–basal stratification of the native human pancreatic duct is differentially represented in pancreatic cancers

Background A resemblance of pancreatic tumours to their native tissue architecture remains largely unexplored, while it may ...
gut.bmj

Colon and rectal cancer survival in seven high-income countries 2010–2014: variation by age and stage at diagnosis (the ICBP SURVMARK-2 project)

Objectives As part of the International Cancer Benchmarking Partnership (ICBP) SURVMARK-2 project, we provide the most recent estimates of colon and rectal cancer survival in seven high-income ...
gut.bmj

IDDF2025-ABS-0331 Metagenomic analysis of gut microbiome dynamics in patients with advanced adenoma: insights into recurrence and non-recurrence

2 Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ...
gut.bmj

Virological response to entecavir is associated with a better clinical outcome in chronic hepatitis B patients with cirrhosis

Objective Entecavir (ETV) is a potent inhibitor of viral replication in chronic hepatitis B and prolonged treatment may result in regression of fibrosis. The aim of this study was to investigate the ...
gut.bmj

Reticulon 3-mediated Chk2/p53 activation suppresses hepatocellular carcinogenesis and is blocked by hepatitis B virus

Correspondence to Dr Yuanyuan Ruan, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; ryyfdu{at}126.com Objective ...
gut.bmj

Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case–control study

Objective To determine the risk of diverticular perforation associated with current and ever use of corticosteroids, opiate analgesics, non-steroidal anti-inflammatory drugs, aspirin, ...
gut.bmj

Mechanisms of intestinal adaptation in short bowel syndrome: what is the evidence?

Short bowel syndrome (SBS) is defined by a remaining small bowel length of less than 200 cm after surgical resection and is a condition with significant clinical implications and a high risk of ...
gut.bmj

Human milk oligosaccharide DSLNT and gut microbiome in preterm infants predicts necrotising enterocolitis

Objective Necrotising enterocolitis (NEC) is a devastating intestinal disease primarily affecting preterm infants. The underlying mechanisms are poorly understood: mother’s own breast milk (MOM) is ...
gut.bmj

Physical activity reshapes intrapancreatic immune and inflammatory programmes to restrain chronic pancreatitis

Background Chronic pancreatitis (CP) is a progressive fibroinflammatory disorder with persistent immune activation and limited therapeutic options. While physical activity (PA) benefits many chronic ...
Gut

Autoimmune gastritis: a hidden gateway to cardia and oesophageal cancers beyond non-cardia gastric adenocarcinoma

Autoimmune gastritis (AIG) has been traditionally recognised as a precursor to type I gastric neuroendocrine tumours and ...
gut.bmj

IDDF2025-ABS-0151 Multi-omics profiling reveals B cell-centric immunosuppressive microenvironment remodelling in hepatocellular carcinoma recurrence

Background Hepatocellular carcinoma (HCC) exhibits a high relapse and low 5-year survival rates. Despite their success in various malignancies, immune checkpoint blockers (ICBs) demonstrate limited ...
gut.bmj

Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review

4 Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia Correspondence to Dr Hashem B El-Serag, Section of Gastroenterology and ...