Massive Russian strikes on Ukraine’s second-largest city killed at least five people on Saturday, officials said, one night after Moscow carried out one of the war’s largest aerial assaults on Ukraine.

Overnight missile and bomb strikes by Russia on the Ukrainian city of Kharkiv left three people dead and 22 hurt, while a Ukrainian drone attack in the Moscow region wounded two people, officials from both countries said separately on Saturday.

A large Russian drone-and-missile attack has targeted Ukraine’s eastern city of Kharkiv, killing at least three people and injuring 21.