A local cancer treatment center is giving patients across West Texas renewed hope by highlighting the life-saving potential of clinical trials.

The Odessa American is the leading source of local news, information, entertainment and sports for the Permian Basin.

Jeran Loschiavo and John Mcclellan have both been arrested in the case. Deputies are searching for 36-year-old Morgan Dewey ...

The Odessa American is the leading source of local news, information, entertainment and sports for the Permian Basin.

This afternoon, Iskander-M OTRK delivered a high-precision strike with two ballistic missiles on the infrastructure of the ...

Several sources have confirmed that the former head men’s basketball coach for Midland College, Tra Arnold, has died. Arnold spent the last three seasons ...

Discover the best staycation spots in Odessa, TX—from cabin rentals to hot tub suites. Local escapes that feel miles away ...

Russia launched two ballistic missiles toward the port of Odessa, resulting in the death of one person and injuries to eight ...

Russia launched two ballistic missiles towards the port of Odessa, resulting in the death of one person and injuries to eight ...

A 33-year-old Odessa man has been arrested for crimes related to the sexual assault of a child, according to the Odessa ...

In observance of Memorial Day, the following City Offices will be closed on Saturday, May 24: Odessa Animal Shelter, Household Hazardous Waste, and the Odessa Recycling Center. City offices that will ...

In Odessa, a series of several explosions once again sounded, which, apparently, were the result of a Russian missile attack.