Learn more about eLife assessments The distribution of synaptic and extra-synaptic AMPA receptors (AMPARs) on neuronal plasma membranes is correlated with learning and memory. Although AMPAR ...

The steroid hormone dafachronic acid may carry the effects of reduced mTOR activity between tissues to coordinate metabolism and longevity across the body.

Cryo-electron tomography uncovers the flexible, filamentous architecture of mouse ciliary rootlets and their regular cross-striations with extensive membrane connections.

This valuable study substantially improves the phylogenetic framework for Kinetoplastea through greatly expanded sampling of free-living neobodonids; the phylogenomic analyses provide convincing ...

eLife reviews research in which approaches from the physical sciences are used to provide insights into the properties of biological systems and processes. Learn more about what we review and sign up ...

Biochemical and structural analyses reveal direct ubiquitin modification of single-stranded nucleic acids, catalysed by the DTX3L ubiquitin ligase.

Crystal structures of γ-protocadherin cell-cell recognition dimers reveal the determinants of clustered protocadherin homophilic specificity and cis interaction region structures alongside mutagenesis ...

Sinisa Pajevic Dietmar Plenz Peter J Basser R Douglas Fields ...

This important study explores the interplay between Legionella Dot/Icm effectors that modulate ubiquitination of the host GTPase Rab10, which undergoes phosphoribosyl-ubiquitination by the SidE family ...

Combination of stem cell engineering and CRISPR technologies created a facile method to genetically manipulate macrophages, a multifunctional cell type that plays critical roles in immunity, cancer, ...

The extent of (proteotoxic) endoplasmic reticulum stress, and the ensuing unfolded protein response activation, are commensurate with the extent of the chaperone BiP being sequestered by its client ...

In prebiotic evolution, molecular self-replicators are considered to develop into diverse, complex living organisms. The appearance of parasitic replicators is believed inevitable in this process.