Gut

Luminal–basal stratification of the native human pancreatic duct is differentially represented in pancreatic cancers

Background A resemblance of pancreatic tumours to their native tissue architecture remains largely unexplored, while it may ...
Gut

Environmental impacts of single-use versus reusable duodenoscopes for endoscopic retrograde cholangiopancreatography in Germany: an ISO-compliant cradle-to-grav…

Duodenoscope-associated infections remain a safety concern, and single-use duodenoscopes have been introduced to mitigate ...
gut.bmj

Colon and rectal cancer survival in seven high-income countries 2010–2014: variation by age and stage at diagnosis (the ICBP SURVMARK-2 project)

Objectives As part of the International Cancer Benchmarking Partnership (ICBP) SURVMARK-2 project, we provide the most recent estimates of colon and rectal cancer survival in seven high-income ...
gut.bmj

IDDF2025-ABS-0104 Lean MASLD: reclassification discrepancies, characteristics, and adverse liver outcomes across diverse populations

2 Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea, South 3 Department of Information Statistics, Andong National University, Andong-si, Gyeongsangbuk-do, Korea, ...
gut.bmj

Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration

Objective Intestinal epithelial cells (IECs) at the internal/external interface orchestrate the mucosal immune response. Paneth cells secrete antimicrobial peptides and inflammatory mediators, protect ...
gut.bmj

Reticulon 3-mediated Chk2/p53 activation suppresses hepatocellular carcinogenesis and is blocked by hepatitis B virus

Correspondence to Dr Yuanyuan Ruan, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; ryyfdu{at}126.com Objective ...
gut.bmj

Mechanisms of intestinal adaptation in short bowel syndrome: what is the evidence?

Short bowel syndrome (SBS) is defined by a remaining small bowel length of less than 200 cm after surgical resection and is a condition with significant clinical implications and a high risk of ...
gut.bmj

Physical activity reshapes intrapancreatic immune and inflammatory programmes to restrain chronic pancreatitis

Background Chronic pancreatitis (CP) is a progressive fibroinflammatory disorder with persistent immune activation and limited therapeutic options. While physical activity (PA) benefits many chronic ...
Gut

Autoimmune gastritis: a hidden gateway to cardia and oesophageal cancers beyond non-cardia gastric adenocarcinoma

Autoimmune gastritis (AIG) has been traditionally recognised as a precursor to type I gastric neuroendocrine tumours and ...
gut.bmj

Early tumour necrosis factor antagonist treatment prevents perianal fistula development in children with Crohn’s disease: post hoc analysis of the RISK study

Background One in three children with Crohn’s disease develop perianal fistula complications (PFCs), among the most disturbing and difficult-to-treat disease-related complications. Retrospective ...
gut.bmj

The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications

4 Department of Hepatogastroenterology, Hopital Claude Huriez, CHRU Lille, France Correspondence to: Professor J-F Colombel Department of Hepato-Gastroenterology, Hopital Claude Huriez, CHRU de Lille, ...
gut.bmj

PTEN deficiency impairs MHC-I-mediated tumour immunity via NRF2-dependent autophagy in microsatellite stable colorectal cancer

Background Immune checkpoint blockade (ICB) has limited efficacy in microsatellite stable (MSS) colorectal cancer (CRC) due to an immunosuppressive tumour microenvironment. Although loss of ...