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jove.com
Video: DNA Methylation Analysis
28.7K Views. Methylation at CpG dinucleotides is a chemical modification of DNA hypothesized to play important roles in regulating gene expression. In particular, the methylation of clusters of methylation sites, called “CpG islands”, near promoters and other gene regulatory elements may contribute to the stable silencing of genes, for ...
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Gene expression, influenced by both DNA and epigenetics, affects emotional regulation and stress responses across generations (Meaney & Szyf, 2005). Trauma-induced epigenetic changes, such as altered DNA methylation, have been observed in descendants of Holocaust survivors (Yehuda et al., 2016) and animals exposed to fear-conditioning (Dias & Ressler, 2014). Variations in 5-HTTLPR (serotonin transport) and COMT (dopamine regulation) genes also contribute to inherited anxiety and mood disorders (
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