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28:15
YouTube
Kendall Smith
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells
In this week's installment of the journal club... The year: 2006 The paper: IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT dependent mechanism and induces the expansion of these cells in vivo. The authors: Zorn E, Nelson EA, Mohseni M, Porcheray F, Kim H, Litsa D, Bellucci R, Raderschall E, Canning C ...
397 views
Aug 29, 2022
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#FOXP3 Gene
FoxP3 (Forkhead box P3) gene expression and Regulatory T cells (Tregs) are at the forefront of future therapies for autoimmune diseases, including Type 1 Diabetes (T1D) and rheumatoid arthritis (RA). Tregs are a specialized subset of CD4 T cells that express the FoxP3 master regulator transcription factor, responsible for suppressing immune responses and maintaining immune tolerance. In autoimmune diseases, these cells are often impaired in number or function, allowing autoreactive immune cells
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