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Your face, neck, and scalp have more estrogen beta receptors than almost anywhere else on your body. That’s why hormonal shifts (especially during perimenopause and menopause) can dramatically affect your skin. Topical estriol is often used to support skin thickness, hydration, and elasticity. It’s targeted to the skin, with minimal absorption elsewhere in the body. But here’s the truth: it doesn’t work for everyone. If your receptors are too depleted or damaged by sun or age, you may not see re